Carbetocin compared to oxytocin in emergency cesarean section: a randomized trial

What Was Tested

The paper reports a study of Oxytocin and Carbetocin, published as a randomized controlled trial.

To evaluate the uterotonic effect of carbetocin compared with oxytocin in emergency cesarean delivery.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, women only.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Oxytocin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Oxytocin, so expectations could not easily colour the readings.

The primary outcome is any additional uterotonic which may be administered by the blinded provider for perceived inadequate uterine tone with or without hemorrhage in the first 24hours after delivery.

Secondary outcomes include operating time, perioperative blood loss, change in hemoglobin and hematocrit levels, blood transfusion and reoperation for postpartum hemorrhage.

What Was Measured

The subject headings attached to it are Cesarean Section, Emergency Treatment, Oxytocics and Oxytocin.

Author keywords: Blood transfusion, Carbetocin and Postpartum hemorrhage.

What This Means in Plain Language

The paper is a randomized and double-blind study of Oxytocin and Carbetocin.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.

More context: the Oxytocin compound page and the Carbetocin compound page.