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Folic Acid, Vitamin B6, and Vitamin B12 in Combination and Age-Related Cataract in a Randomized Trial of Women
Plain-language guide to PMID 26786311 (2016): double-blind randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 3925 women.
Key Facts
- PMID
- 26786311
- Journal
- Ophthalmic epidemiology
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Christen WG et al. (5 authors)
- DOI
- 10.3109/09286586.2015.1130845
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
To examine the incidence of cataract and cataract extraction in a trial of folic acid and vitamins B6 and B12.
Who Took Part
The abstract describes 3925 women taking part.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, women only.
A total of 3925 of these women did not have a diagnosis of cataract at baseline and were included in this analysis.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The women were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
Neither the women nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Cyanocobalamin (Vitamin B12) group a baseline to be compared against.
Extraction of incident age-related cataract was a secondary endpoint of the trial.
What Was Measured
PubMed files the paper under topics including Cardiovascular Diseases, Cataract, Cataract Extraction, Drug Combinations, Folic Acid, Health Personnel and Incidence.
The authors tagged it with the keywords Women’s Antioxidant Folic Acid Cardiovascular Study, randomized controlled trial, supplements, vitamin B12 and vitamin B6.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 3925 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2016 (Ophthalmic epidemiology), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.