Women may respond different from men to vitamin D supplementation regarding cardiometabolic biomarkers.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

As a result, assessing gender differences regarding the effects of vitamin D supplementation on some cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease (NAFLD) was the aim of present study.

Why It Was Studied

Moreover, few gender-specific analyses have been performed in the clinical trials regarding vitamin D supplementation.

The researchers conducted a post hoc subgroup analysis of a double blind placebo controlled study.

Who Took Part

The study group was 27, men.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the men nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some men received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Serum lipid profiles, aminotransferases, high-sensitive C-reactive protein (hs-CRP), adiponectin as well as insulin resistance and dietary intakes were assessed pre- and post-study.

What Was Measured

Topics PubMed links to this paper include Adiponectin, Biomarkers, C-Reactive Protein, Cholesterol, Cholesterol, LDL, Dietary Supplements and Insulin Resistance.

Author keywords: Vitamin D, cardiometabolic biomarkers, gender and non-alcoholic fatty liver disease.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 27, men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2016 (Experimental biology and medicine (Maywood, N.J.)), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.