Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years: The VDAART Randomized Clinical Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

According to the abstract, 436 women were involved.

PubMed indexes the participants as young children, young adults and adults, both men and women.

Enrollment began in October 2009 and completed follow-up in January 2015.

Eight hundred eighty-one pregnant women between the ages of 18 and 39 years at high risk of having children with asthma were randomized at 10 to 18 weeks' gestation.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Five participants were deemed ineligible shortly after randomization and were discontinued.

What Was Measured

Topics PubMed links to this paper include Asthma, Cholecalciferol, Dietary Supplements, Fetal Blood, Pregnancy Trimester, Third, Recurrence and Respiratory Sounds.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 436 women.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (JAMA), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.