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Bone Mineral Density and Parathyroid Hormone as Independent Risk Factors for Mortality in Community-Dwelling Older Adults: A Population-Based Prospective Cohort Study in Brazil. The São Paulo Ageing & Health (SPAH) Study
Plain-language guide to PMID 26814375 (2016): clinical trial study of Parathyroid Hormone (PTH 1-84) in 839 subjects.
Key Facts
- PMID
- 26814375
- Journal
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Year
- 2016
- Study type
- Clinical Trial
- Authors
- Domiciano DS et al. (9 authors)
- DOI
- 10.1002/jbmr.2795
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a clinical trial.
Thus, the researchers sought to investigate the association between bone parameters and mortality in a longitudinal, prospective, population-based cohort of 839 elderly subjects.
Why It Was Studied
However, none of these studies performed a concomitant evaluation of the parathyroid hormone (PTH)-calcium-vitamin D axis and bone mass to accurately determine the contribution of each of these parameters to survival in older subjects.
Laboratory exams, including serum 25OHD and PTH, were also performed.
Who Took Part
The abstract describes 839 subjects taking part.
PubMed indexes the participants as older adults and people over 80, both men and women.
How the Study Was Run
Clinical data (including history of fractures and cardiovascular events) were assessed using a specific questionnaire.
Bone mineral density (BMD) at the lumbar spine and hip were evaluated using DXA.
What Was Measured
However, none of these studies performed a concomitant evaluation of the parathyroid hormone (PTH)-calcium-vitamin D axis and bone mass to accurately determine the contribution of each of these parameters to survival in older subjects.
Topics PubMed links to this paper include Accidental Falls, Bone Density, Brazil, Cardiovascular Diseases, Mortality, Parathyroid Hormone and Vitamin D.
Author keywords: BONE MINERAL DENSITY, ELDERLY and RISK FACTORS.
What This Means in Plain Language
This is a clinical trial of Parathyroid Hormone (PTH 1-84) in 839 subjects.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2016 (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.