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Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial.
Plain-language guide to PMID 26817502 (2016): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 26817502
- Journal
- The American journal of clinical nutrition
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Barnett JB et al. (11 authors)
- DOI
- 10.3945/ajcn.115.115188
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Zinc is essential for the regulation of immune response.
T cell function declines with age.
Who Took Part
PubMed indexes the participants as older adults and people over 80, both men and women.
The researchers also explored the effects of supplementation on immune response.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
This was a randomized, double-blind, placebo-controlled study.
The primary outcome measure was change in serum zinc concentrations between baseline and month 3.
What Was Measured
The subject headings attached to it are Aging, Cell Proliferation, Deficiency Diseases, Dietary Supplements, Homes for the Aged, Lymphocyte Activation and Nursing Homes.
The authors tagged it with the keywords T cell proliferation, nursing home elderly, serum zinc concentration, zinc gluconate and zinc supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2016 (The American journal of clinical nutrition), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.