Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Their objective was to perform exploratory analyses on the prospective associations between the plasma 25-hydroxyvitamin D [25(OH)D] concentration, polymorphisms of genes encoding for the vitamin D receptor (VDR) and vitamin D-binding protein (also known as gc-globulin or group-specific component, GC), and breast cancer risk, along with 2 potential modifiers: body mass index (BMI; in kg/m(2)) and alcohol intake.

Who Took Part

The abstract describes 233 women taking part.

PubMed indexes the participants as adults, middle-aged adults and older adults, women only.

A nested case-control study was set up in the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort (1994-2007), involving 233 women with breast cancer and 466 matched controls (mean ± SD age: 49 ± 6 y).

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The plasma total 25(OH)D concentration and gene polymorphisms were assessed on samples obtained at baseline.

Conditional logistic regression models were computed.

What Was Measured

PubMed files the paper under topics including Alcohol Drinking, Body Mass Index, Breast Neoplasms, Case-Control Studies, Dietary Supplements, Logistic Models and Polymorphism, Single Nucleotide.

The authors tagged it with the keywords 25-hydroxyvitamin D, alcohol intake, breast cancer risk, nested case-control study, single nucleotide polymorphisms and vitamin D binding protein.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 233 women.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.