A randomised controlled trial evaluating the impact of targeted vitamin D supplementation on endothelial function in type 2 diabetes mellitus: The DIMENSION trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The researchers compared the change from baseline parameters in the two groups using Student's t-test or Kruskal-Wallis test.

Who Took Part

According to the abstract, 2 patients were involved.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Endothelial function was assessed by peripheral tonometry (reactive hyperaemia index-endothelial peripheral arterial tonometry) and vascular biomarkers: E-selectin, von-Willebrand factor and high-sensitivity C-reactive protein.

What Was Measured

The researchers compared the change from baseline parameters in the two groups using Student's t-test or Kruskal-Wallis test.

PubMed files the paper under topics including Biomarkers, Cholecalciferol, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Dietary Supplements, Endothelium, Vascular and Hyperemia.

Author keywords: Vitamin D, endothelial function and type 2 diabetes.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 2 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2016 (Diabetes & vascular disease research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.