Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study.

What Was Tested

The paper reports a study of Collagen Type II, published as a randomized controlled trial.

Undenatured type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

Modified intent-to-treat analysis were performed for all endpoints using analysis of covariance and mixed model repeated measures, while incremental area under the curve was calculated by the intent-to-treat method.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Collagen Type II study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Collagen Type II study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Collagen Type II could be set against what happens without it.

The primary endpoint was the change in total Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) from baseline through day 180 for the UC-II group versus placebo and GC.

Secondary endpoints included the Lequesne Functional Index (LFI), the Visual Analog Scale (VAS) for pain and the WOMAC subscales.

What Was Measured

The subject headings attached to it are Biomarkers, Body Mass Index, C-Reactive Protein, Cartilage Oligomeric Matrix Protein, Collagen Type II, Dietary Supplements and Interleukin-6.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Collagen Type II.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (Nutrition journal), a journal based in England.

More context: all human trials.