Vitamin D status in relation to Crohn's disease: Meta-analysis of observational studies.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a meta-analysis.

Inconsistent findings have been published regarding vitamin D status among patients with Crohn's disease (CD) and the association with disease severity.

The researchers aimed to perform a meta-analysis evaluating serum 25-hydroxy vitamin D and 1,25 dehydroxyvitamin D among CD patients compared with healthy and non-healthy controls, the prevalence of vitamin D deficiency, and the association with disease.

Who the Included Studies Covered

By PubMed's age tags, the people studied were children and adults.

The researchers searched MEDLINE, SCOPUS, EMBASE, and Google Scholar up to March 2015 for observational studies assessing serum vitamin D levels in CD patients.

A total of 63 studies were included in the following four meta-analyses: 1) a meta-analysis on the mean difference of 25(OH)D levels in CD patients compared with healthy (number of studies = 27) and non-healthy (n = 25) controls; 2) a meta-analysis on the mean difference of 1,25(OH)2 D3 levels in CD patients compared with healthy (n = 7) and non-healthy (n = 8) controls; 3) a meta-analysis on the prevalence of vitamin D deficiency (n = 34); 4) a meta-analysis on the correlation coefficients between vitamin D status severity of CD (n = 6).

How the Review Was Done

Subgroup analysis and meta-regression were used to discover possible sources of between-study heterogeneity.

What Was Measured

The subject headings attached to it are 25-Hydroxyvitamin D 2, Crohn Disease, Evidence-Based Medicine, Global Health, Nutritional Status, Observational Studies as Topic and Prevalence.

Author keywords: Crohn's disease, Deficiency, Disease activity, Meta-analysis and Vitamin D status.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (Nutrition (Burbank, Los Angeles County, Calif.)), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.