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Vitamin D3 for uncontrolled childhood asthma: A pilot study.
Plain-language guide to PMID 26845753 (2016): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 26845753
- Journal
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Kerley CP et al. (7 authors)
- DOI
- 10.1111/pai.12547
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers aimed to assess the effect of 15 weeks of vitamin D3 supplementation compared with placebo (PL) in Irish children with asthma.
Why It Was Studied
However, subsequent interventional trials have been inconsistent.
Who Took Part
PubMed indexes the participants as children, both men and women.
Outcome measures were lung function, subjective asthma control and biochemical parameters of total vitamin D, allergy, immunity, airway inflammation, and systemic inflammation.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and pilot study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
The subject headings attached to it are Absenteeism, Asthma, Biomarkers, Cholecalciferol, Forced Expiratory Volume, Ireland and Lung.
Author keywords: allergy, bone, infection, pediatric, pulmonary function and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2016 (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.