Effect of Resveratrol-Based Nutritional Supplement on Choroidal Thickness: A Pilot Study.

What Was Tested

This randomized controlled trial looks at Antioxidants.

The effect of an oral trans-resveratrol-based supplement (Longevinex®) on choroidal thickness, measured using optical coherence tomography (OCT) enhanced depth imaging, was investigated in a prospective study.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, both men and women.

34 young, healthy participants were randomly divided into two age- and gender-matched groups.

All participants underwent ocular imaging with spectral domain (SD)-OCT (Spectralis; Heidelberg Engineering, Heidelberg) at the baseline and then again 1 h following treatment.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and pilot study.

Because people in this Antioxidants study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Antioxidants, so expectations could not easily colour the readings.

Some participants received a placebo instead of Antioxidants, giving a reference point.

It is described as a pilot, a small early test of whether a larger Antioxidants study would be practical.

They were then assigned in a randomized fashion to treat with either a trans-resveratrol-based group (Longevinex®, Las Vegas) or placebo.

The choroidal thickness was measured in a masked fashion at the fovea and at four additional points, located at 500 μm and 1000 μm nasal to the fovea and 500 μm and 1000 μm temporal to the fovea.

What Was Measured

Topics PubMed links to this paper include Antioxidants, Choroid, Dietary Supplements, Healthy Volunteers, Pilot Projects, Resveratrol and Stilbenes.

The authors tagged it with the keywords Choroidal blood flow, choroidal thickness, enhanced depth imaging, optical coherence tomography and trans-resveratrol.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Antioxidants.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (Current eye research), a journal based in England.

More context: all human trials.