Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this clinical trial publication.

This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children.

Who Took Part

According to the abstract, 466 infants were involved.

By PubMed's age tags, the people studied were infants and adults, both men and women.

A case-cohort sample of 466 South African infants enrolled in P1041 trial (NCT00080119) underwent 25-hydroxyvitamin D testing by chemiluminescent immunoassay.

How the Study Was Run

Single nucleotide polymorphisms (SNPs) that alter the effect of vitamin D [e.g. vitamin D receptor (VDR)], vitamin D levels [e.g. vitamin D binding protein (VDBP)], or toll like receptor (TLR) expression (SIGIRR including adjacent genes PKP3 and TMEM16J) were identified by real-time PCR.

Effect modification between vitamin D status and SNPs for outcomes was assessed.

What Was Measured

This study examined the associations of 25-hydroxyvitamin D and specific host genetic variants that affect vitamin D levels or its effects on immune function, with the risk of TB or mortality in children.

Topics PubMed links to this paper include Anoctamins, Cohort Studies, Gene Expression, Genetic Predisposition to Disease, HIV Infections, Membrane Proteins and Phospholipid Transfer Proteins.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 466 infants.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (PloS one), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.