Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community.

What Was Tested

The paper reports a study of Aequorin, published as a randomized controlled trial.

The study was designed to assess the effects of a supplement of apoaequorin on verbal learning and working memory.

Why It Was Studied

As humans age, the body's ability to regulate and maintain calcium levels is diminished.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.

Participants were 218 community-dwelling adults, aged 40-91 y, with self-reported memory concerns.

Participants were randomly assigned to receive either apoaequorin (apoaequorin group) or a matched placebo (control group) for 90 d.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Aequorin and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Aequorin.

The comparison arm used a placebo, so changes seen with Aequorin could be set against what happens without it.

The current study, the Madison Memory Study, was a randomized, double-blind, placebo-controlled trial.

The study occurred in Madison, WI, USA.

What Was Measured

As humans age, the body's ability to regulate and maintain calcium levels is diminished.

PubMed files the paper under topics including Aequorin, Aging, Apoproteins, Cognition, Dietary Supplements, Neuropsychological Tests and Recombinant Proteins.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Aequorin.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (Advances in mind-body medicine), a journal based in United States.

More context: all human trials.