← Human Trials & Peer-Reviewed Studies
Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Plain-language guide to PMID 26954409 (2016): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, osteoarthritis, cartilage loss & avoiding joint replacement.
Key Facts
- PMID
- 26954409
- Journal
- JAMA
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Jin X et al. (11 authors)
- DOI
- 10.1001/jama.2016.1961
- Registered trial
- NCT01176344
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of osteoarthritis, cartilage loss & avoiding joint replacement, published as a randomized controlled trial.
To compare the effects of vitamin D supplementation vs placebo on knee pain and knee cartilage volume in patients with symptomatic knee osteoarthritis and low vitamin D levels.
Why It Was Studied
Clinicaltrials.gov Identifier: NCT01176344; anzctr.org.au Identifier: ACTRN12610000495022.
Who Took Part
PubMed indexes the participants as middle-aged adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and multicenter.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
More than one site took part, so the participants came from several places.
A multicenter randomized, double-blind, placebo-controlled clinical trial in Tasmania and Victoria, Australia.
The trial was completed in December 2013.
What Was Measured
Topics PubMed links to this paper include Arthralgia, Cartilage, Cholecalciferol, Knee Joint, Magnetic Resonance Imaging, Osteoarthritis, Knee and Pain Measurement.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with osteoarthritis, cartilage loss & avoiding joint replacement.
Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2016 (JAMA), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Osteoarthritis, cartilage loss & avoiding joint replacement research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
- Osteoarthritis, cartilage loss & avoiding joint replacement research
- Vitamin D, K2, Magnesium and Zinc in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.