← Human Trials & Peer-Reviewed Studies
Calcitonin gene-related peptide induced migraine attacks in patients with and without familial aggregation of migraine
Plain-language guide to PMID 26994300 (2017): double-blind randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide), migraine.
Key Facts
- PMID
- 26994300
- Journal
- Cephalalgia : an international journal of headache
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Guo S et al. (6 authors)
- DOI
- 10.1177/0333102416639512
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of CGRP (Calcitonin Gene-Related Peptide) in the context of migraine, published as a randomized controlled trial.
Whether aggregation of migraine in first-degree relatives (family load) or a high number of risk-conferring single nucleotide polymorphisms contributes to migraine susceptibility to calcitonin gene-related peptide infusion in migraine patients is unknown.
The researchers hypothesized that genetic enrichment plays a role in triggering of migraine and, therefore, migraine without aura patients with high family load would report more migraine attacks after calcitonin gene-related peptide infusion than patients with low family load.
Who Took Part
PubMed indexes the participants as young adults, adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
Because people in this CGRP (Calcitonin Gene-Related Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the participants and researchers unaware of who received CGRP (Calcitonin Gene-Related Peptide).
What Was Measured
Information of familial aggregation was obtained by telephone interview of first-degree relatives using a validated semi-structured questionnaire.
The subject headings attached to it are Calcitonin Gene-Related Peptide, Cohort Studies, Migraine Disorders, Migraine with Aura and Surveys and Questionnaires.
Author keywords: familial aggregation, migraine without aura, risk alleles and single nucleotide polymorphisms.
What This Means in Plain Language
The paper is a randomized and double-blind study of CGRP (Calcitonin Gene-Related Peptide) in people with migraine.
The publication is from 2017 (Cephalalgia : an international journal of headache), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.