Effects of Fixed Orthodontic Treatment Using Conventional, Copper-Included, and Epoxy-Coated Nickel-Titanium Archwires on Salivary Nickel Levels: A Double-Blind Randomized Clinical Trial.

Plain-language guide to PMID 27048275 (2016): double-blind randomized controlled trial of Copper (Supplement) in 42 patients.

Key Facts

PMID: 27048275
Journal: Biological trace element research
Year: 2016
Study type: Randomized Controlled Trial
Authors: Khaneh Masjedi M et al. (5 authors)
DOI: 10.1007/s12011-016-0690-7

What This Study Did, in Plain Language

What Was Tested

Researchers studied Copper (Supplement) in this randomized controlled trial publication.

Orthodontic archwires, especially nickel-titanium (NiTi) ones, are a major source of nickel release.

Despite their importance, no in vivo studies have assessed the ion release from conventional or new generations of NiTi archwires (copper-included and epoxy-coated).

Who Took Part

According to the abstract, 42 patients were involved.

By PubMed's age tags, the people studied were teenagers and adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind and parallel-group study.

Because people in this Copper (Supplement) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the patients nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.

Groups ran in parallel: each of the patients stayed in one arm throughout.

What Was Measured

Despite their importance, no in vivo studies have assessed the ion release from conventional or new generations of NiTi archwires (copper-included and epoxy-coated).

Topics PubMed links to this paper include Alloys, Coated Materials, Biocompatible, Copper, Orthodontic Wires and Saliva.

The authors tagged it with the keywords Atomic absorption spectrophotometry, Copper nickel-titanium (NiTiCu) archwires, Epoxy-coated nickel-titanium archwires, Metal injection molding (MIM) brackets, Nickel-titanium archwires and Orthodontic treatment.

What This Means in Plain Language

The paper is a randomized, double-blind and parallel-group study of Copper (Supplement) in 42 patients.

The publication is from 2016 (Biological trace element research), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.

Our Notes on the Compound

Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.

Copper (Supplement) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.