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Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.
Plain-language guide to PMID 27058906 (2016): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 229 patients.
Key Facts
- PMID
- 27058906
- Journal
- Journal of the American College of Cardiology
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Witte KK et al. (17 authors)
- DOI
- 10.1016/j.jacc.2016.03.508
- Registered trial
- NCT01619891
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D.
Who Took Part
According to the abstract, 229 patients were involved.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
The primary endpoint was change in 6-minute walk distance between baseline and 12 months.
Secondary endpoints included change in LV ejection fraction at 1 year, and safety measures of renal function and serum calcium concentration assessed every 3 months.
What Was Measured
Patients with chronic heart failure (HF) secondary to left ventricular systolic dysfunction (LVSD) are frequently deficient in vitamin D.
PubMed files the paper under topics including Calcifediol, Calcitriol, Cholecalciferol, Echocardiography, Heart Failure, Heart Ventricles and Magnetic Resonance Imaging, Cine.
Author keywords: left ventricular function, remodeling and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 229 patients.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2016 (Journal of the American College of Cardiology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.