Effects of Food and Pharmaceutical Formulation on Desmopressin Pharmacokinetics in Children

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

Desmopressin is used for treatment of nocturnal enuresis in children.

Who Took Part

The abstract describes 22 children taking part.

PubMed indexes the participants as children and teenagers, both men and women.

A one-compartment model with first-order absorption was fitted to the data.

How the Study Was Run

In design terms this was a randomized and crossover study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In the crossover set-up each of the children took both Vasopressin and the comparison in turn, acting as their own control.

Covariates were selected using a forward selection procedure.

Simulations were subsequently performed to further explore the relative bioavailability of both formulations and the food effect.

What Was Measured

Topics PubMed links to this paper include Antidiuretic Agents, Biological Availability, Deamino Arginine Vasopressin, Drug Compounding, Fasting, Food and Models, Biological.

What This Means in Plain Language

The paper is a randomized and crossover study of Vasopressin and Desmopressin in 22 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (Clinical pharmacokinetics), a journal based in Switzerland.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.