Preoperative Urodynamic Parameters (Valsalva Leak Point Pressure and Maximum Urethral Closure Pressure), Urinary Collagen and Plasma Vitamin D Levels as Predictors of Mid Urethral Sling Surgery Outcome.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

To determine the best predictor of the mid urethral sling outcome the researchers calculated the AUC of ROC curves of preoperative parameters, including Valsalva leak point pressure, maximum urethral closure pressure, urinary NTx (N-telopeptide of crosslinked type I collagen) and plasma vitamin D values (D2, D3 and D2 plus D3).

Outcome success was defined using identical outcome (subjective and objective) variables for all subjects.

Who Took Part

The abstract describes 427 subjects taking part.

By PubMed's age tags, the people studied were middle-aged adults, women only.

This was an ancillary study of TOMUS (Trial of Mid-urethral Slings) and the ValUE (Value of Urodynamics Evaluation) trial in which subjects underwent mid urethral sling surgery for stress urinary incontinence.

Valsalva leak point pressure and maximum urethral closure pressure were measured in 427 subjects, whereas NTx, vitamin D2, vitamin D3 and vitamin D2 plus D3 levels were obtained from 150, 116, 115 and 116 subjects respectively.

How the Study Was Run

The design is described as randomized.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

ROC curves with corresponding AUC values were compared.

What Was Measured

PubMed files the paper under topics including Biomarkers, Body Mass Index, Collagen, Pressure, Prognosis, Risk Factors and Suburethral Slings.

Author keywords: outcome assessment (health care) and urodynamics.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 427 subjects.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (The Journal of urology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.