[THE INFLUENCE OF ANAESTHESIA ON PERIOPERATIVE VALUES OF AMINOTERMINAL FRAGMENT OF THE BRAIN NATRIURETIC PEPTIDE PRECUSSOR IN PATIENT WITH POSTINFARCTION CARDIOSCLEROSIS UNDERGOING NONCARDIAC SURGERY]

What Was Tested

This randomized controlled trial paper looks at BNP (Nesiritide).

The effects of general and spinal anaesthesia on perioperative dynamics of NTproBNP in patients with postinfarction cardiosclerosis in the surgical treatment of benign prostatic hyperplasia.

Why It Was Studied

The importance of postoperative values of cardiac damage biomarkers studying (such as troponine and NTproBNP) is stressed by recommendations of the European Society of Cardiology and the European Society of Anaesthesiologists (2014).

Who Took Part

The study group was 67 men.

PubMed indexes the participants as middle-aged adults and older adults, men only.

67 men aged 60 to 75 years were included in a prospective, randomized study.

Patients were undergone elective open surgery for prostatic hyperplasia.

How the Study Was Run

The researchers set it up as a randomized study.

The men were allocated by chance, so the BNP (Nesiritide) group and the comparison group should start out alike.

All patients had a history of myocardial infarction.

Depending on the type of anaesthesia the patients were divided into 2 groups: The first group (35) was operated under spinal anaesthesia (SA).

The second group (32) was operated under general anaesthesia (GA).

Determining the level of NTproBNP in the venous blood plasma realized four times: 1 hour before surgery, at once at the end of surgery, 12 and 24 hour after surgery.

What Was Measured

Topics PubMed links to this paper include Anesthesia, General, Anesthesia, Spinal, Biomarkers, Myocardial Infarction, Myocardium, Natriuretic Peptide, Brain and Peptide Fragments.

What This Means in Plain Language

The paper is a randomized study of BNP (Nesiritide) in 67 men.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (Anesteziologiia i reanimatologiia), a journal based in Russia (Federation).

More context: the BNP (Nesiritide) compound page, all human trials.