The endometrial preparation for frozen-thawed euploid blastocyst transfer: a prospective randomized trial comparing clinical results from natural modified cycle and exogenous hormone stimulation with GnRH agonist

What Was Tested

This randomized controlled trial paper looks at hCG (human chorionic gonadotropin) in the context of endometriosis.

The aim of the study was to evaluate two methods of endometrial preparation for frozen-thawed single euploid blastocyst transfer: modified natural and artificial cycle with GnRH-agonist pituitary suppression.

Who Took Part

The study group was 236 patients.

By PubMed's age tags, the people studied were adults, women only.

In this prospective, controlled randomized trial, a total of 236 patients undergoing infertility treatment were randomized in 1:1 ratio; 118 received a frozen-thawed single euploid blastocyst transfer in a modified natural cycle and 118 in an artificial cycle with GnRH-agonist pituitary suppression.

How the Study Was Run

In design terms this was a randomized study.

The patients were allocated by chance, so the hCG (human chorionic gonadotropin) group and the comparison group should start out alike.

In the artificial protocol, GnRH-agonist combined with estradiol valerate was administered.

In the natural protocol, only final oocyte maturation was induced using human chorionic gonadotropin administration.

What Was Measured

PubMed files the paper under topics including Abortion, Spontaneous, Anxiety, Chorionic Gonadotropin, Cryopreservation, Depression, Embryo Implantation and Embryo Transfer.

The authors tagged it with the keywords Blastocyst transfer, Endometrial preparation, Euploid embryos and Vitrification.

What This Means in Plain Language

The paper is a randomized study of hCG (human chorionic gonadotropin) in 236 patients in people with endometriosis.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (Journal of assisted reproduction and genetics), a journal based in Netherlands.

More context: the hCG (human chorionic gonadotropin) compound page, Endometriosis research.