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Zinc supplementation for improving glucose handling in pre-diabetes: A double blind randomized placebo controlled pilot study.
Plain-language guide to PMID 27242121 (2016): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 224 patients.
Key Facts
- PMID
- 27242121
- Journal
- Diabetes research and clinical practice
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Islam MR et al. (13 authors)
- DOI
- 10.1016/j.diabres.2016.03.010
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Who Took Part
The abstract describes 224 patients taking part.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
The Bangladesh Institute of Health Sciences Hospital (BIHS) (Mirpur, Dhaka, Bangladesh) database was used to identify 224 patients with prediabetes, of whom 55 met the inclusion criteria and agreed to participate.
The participants were randomized either to the intervention or control group using block randomization.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
PubMed files the paper under topics including Blood Glucose, Dietary Supplements, Glucose, Hypoglycemic Agents, Insulin Resistance, Pilot Projects and Prediabetic State.
The authors tagged it with the keywords Bangladesh, Pre-diabetes and Zinc.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 224 patients.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2016 (Diabetes research and clinical practice), a journal based in Ireland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.