The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study aimed to assess whether vitamin D supplementation can slow the rate of progression.

Who Took Part

According to the abstract, 474 patients were involved.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Primary outcome was difference in rate of medial joint space narrowing (JSN).

Secondary outcomes included lateral JSN, Kellgren & Lawrence grade, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, stiffness and the Get up and Go test.

What Was Measured

The subject headings attached to it are Knee Joint, Osteoarthritis, Knee, Vitamin D and Vitamins.

Author keywords: Randomised placebo-controlled trial.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 474 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (Osteoarthritis and cartilage), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.