Effects of Calcium-Vitamin D and Calcium-Alone on Pain Intensity and Menstrual Blood Loss in Women with Primary Dysmenorrhea: A Randomized Controlled Trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The authors aimed to determine the effect of combined calcium-vitamin D and calcium-alone on pain intensity and menstrual blood loss in women with primary dysmenorrhea.

Why It Was Studied

This study was approved by the Ethics committee of Tabriz University of Medical Sciences (code 92145) and registered at the Iranian Registry of Clinical Trials with IRCT201402043706N21.

Who Took Part

PubMed indexes the participants as teenagers, young adults and adults, women only.

85 students with moderate or severe primary dysmenorrhea.

Pain intensity and menstrual blood loss were assessed one cycle before, three cycles under, and one cycle following intervention using 10-cm visual analog scale and pictorial blood loss assessment chart, respectively.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Dormitories of Tabriz University of Medical Sciences.

The groups were compared using repeated measures ANOVA.

What Was Measured

Topics PubMed links to this paper include Calcium, Cholecalciferol, Dysmenorrhea, Menstruation and Pain.

The authors tagged it with the keywords Calcium-Vitamin D, Clinical Trial, Menstrual Bleeding, Pain Intensity and Primary Dysmenorrhea.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (Pain medicine (Malden, Mass.)), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.