Effect of Lactobacillus rhamnosus GG and vitamin D supplementation on the immunologic effectiveness of grass-specific sublingual immunotherapy in children with allergy.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

PubMed indexes the participants as young children and children, both men and women.

One hundred children, ages 5-12 years, sensitive to grass pollen, with allergic rhinitis participated in a 5-month prospective, randomized, double-blind, placebo-controlled trial.

The control group included children with allergy who did not qualify for immunotherapy.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Primary end points included a symptom-medication score, lung function, and exhaled nitric oxide concentration.

What Was Measured

PubMed files the paper under topics including Allergens, Biomarkers, Case-Control Studies, Dietary Supplements, Lacticaseibacillus rhamnosus, Poaceae and Pollen.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2016 (Allergy and asthma proceedings), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.