A study of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer after two or more implantation failures

What Was Tested

The paper reports a study of hCG (human chorionic gonadotropin), published as a randomized controlled trial.

To investigate the effect of intrauterine infusion of human chorionic gonadotropin (hCG) before frozen-thawed embryo transfer (FET) after two or more implantation failures (TIFs).

Who Took Part

According to the abstract, 161 patients were involved.

The age groups tagged for this paper are adults, women only.

The study was a prospective randomized single-blind study of 161 cycles in patients undergoing FET who had TIFs.

How the Study Was Run

The researchers set it up as a randomized, single-blind and placebo-controlled study.

Because people in this hCG (human chorionic gonadotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In this single-blind hCG (human chorionic gonadotropin) study one party knew the assignments and the other did not.

Some patients received a placebo instead of hCG (human chorionic gonadotropin), giving a reference point.

A placebo group (n = 49) received an intrauterine injection of physiological saline before ET.

A control group (n = 50) did not receive an intrauterine injection.

Clinical pregnancy rates, abortion rates, and ongoing pregnancy rates were compared between the three groups.

What Was Measured

The subject headings attached to it are Chorionic Gonadotropin, Cryopreservation, Embryo Implantation, Embryo Transfer, Fertilization in Vitro, Infusions, Parenteral and Outcome Assessment, Health Care.

The authors tagged it with the keywords Frozen-thawed embryo transfer, IVF, hCG and intrauterine infusion.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of hCG (human chorionic gonadotropin) in 161 patients.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology), a journal based in England.

More context: the hCG (human chorionic gonadotropin) compound page, all human trials.