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Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial
Plain-language guide to PMID 27483065 (2016): double-blind randomized controlled trial study of Vasopressin in 2015, patients.
Key Facts
- PMID
- 27483065
- Journal
- JAMA
- Year
- 2016
- Study type
- Randomized Controlled Trial
- Authors
- Gordon AC et al. (13 authors)
- DOI
- 10.1001/jama.2016.10485
- Registered trial
- NCT06344442, NCT05506319
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vasopressin in this randomized controlled trial publication.
To compare the effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock.
Why It Was Studied
Norepinephrine is currently recommended as the first-line vasopressor in septic shock; however, early vasopressin use has been proposed as an alternative.
Who Took Part
According to the abstract, 2015, patients were involved.
The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.
A factorial (2×2), double-blind, randomized clinical trial conducted in 18 general adult intensive care units in the United Kingdom between February 2013 and May 2015, enrolling adult patients who had septic shock requiring vasopressors despite fluid resuscitation within a maximum of 6 hours after the onset of shock.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
The patients were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on Vasopressin, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vasopressin could be set against what happens without it.
What Was Measured
The subject headings attached to it are Critical Care, Fluid Therapy, Hydrocortisone, Intensive Care Units, Norepinephrine, Renal Insufficiency and Renal Replacement Therapy.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin in 2015, patients.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2016 (JAMA), a journal based in United States.
More context: the Vasopressin compound page.
Our Notes on the Compound
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.