Daily Cholecalciferol Supplementation during Pregnancy Alters Markers of Regulatory Immunity, Inflammation, and Clinical Outcomes in a Randomized Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Vitamin D supplementation in pregnancy may support the maintenance of pregnancy by its effects on innate and adaptive immunity.

Who Took Part

The study group was 57 women.

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Vitamin D status, regulatory and inflammatory T cells, markers of innate immunity and systemic inflammation, and clinical outcomes including maternal blood pressure and birth weight were assessed at 26 and 36 wk of pregnancy.

What Was Measured

Topics PubMed links to this paper include Biomarkers, CD4-Positive T-Lymphocytes, Cholecalciferol, Cytokines, Dietary Supplements, Inflammation and Interleukin-10.

The authors tagged it with the keywords T cell, clinical trial, pregnancy and vitamin D.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 57 women.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2016 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.