Effect of Resected Gastric Volume on Ghrelin and GLP-1 Plasma Levels: a Prospective Study

What Was Tested

The paper reports a study of Ghrelin, published as an observational study.

The correlation between resected gastric volume (RGV) and neuro-humoral changes (ghrelin and GLP-1) after laparoscopic sleeve gastrectomy (LSG) and their effects on type 2 diabetes mellitus (T2DM) has been evaluated.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Insulin secretion (insulin area under the curve (AUC)), insulinogenic index (IGI) and insulin-resistance (homeostasis model assessment, HOMAIR) were assessed before and after surgery (at the 3rd day and 6, 12 and 24 months after LSG) using the oral glucose tolerance test (OGTT).

How the Study Was Run

At the same time, ghrelin and GLP-1 levels were determined.

What Was Measured

The correlation between resected gastric volume (RGV) and neuro-humoral changes (ghrelin and GLP-1) after laparoscopic sleeve gastrectomy (LSG) and their effects on type 2 diabetes mellitus (T2DM) has been evaluated.

Topics PubMed links to this paper include Bariatric Surgery, Diabetes Mellitus, Type 2, Gastrectomy, Ghrelin, Glucagon-Like Peptide 1, Glucose Tolerance Test and Insulin.

The authors tagged it with the keywords Diabetes mellitus type 2, Obesity, Sleeve gastrectomy and Volume resected.

What This Means in Plain Language

This is an observational study of Ghrelin.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2016 (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract), a journal based in Netherlands.

More context: the Ghrelin compound page, all human trials.