Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial.

What Was Tested

Researchers studied Copper (Supplement) in this randomized controlled trial publication.

General clinical assessment, evaluation using the Greene climacteric test and Spielberger-Hanin test, determination of plasma levels of gonadotropins, estradiol, leptin and apolipoproteins were used to evaluate 42-60-year-old women with vasomotor and psychosomatic menopausal symptoms.

Why It Was Studied

Peri- and postmenopausal women commonly suffer from climacteric symptoms.

Who Took Part

The abstract describes 21 women taking part.

PubMed indexes the participants as adults and middle-aged adults, women only.

One hundred and twenty-five women were enrolled in the study and randomized between two groups.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Copper (Supplement) and who got the comparison, which limits bias.

Neither the women nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.

Some women received a placebo instead of Copper (Supplement), giving a reference point.

What Was Measured

PubMed files the paper under topics including Dietary Supplements, Menopause, Minerals, Outcome Assessment, Health Care, Succinic Acid and Vitamin E.

Author keywords: Ammonium succinate, menopausal symptoms treatment, mitochondrial dysfunction and vasomotor and psychosomatic menopause symptoms.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in 21 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2016 (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology), a journal based in England.

More context: the Copper (Supplement) compound page, all human trials.