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Combination treatment of nocturnal enuresis with desmopressin and indomethacin
Plain-language guide to PMID 27787700 (2017): double-blind randomized controlled trial study of Vasopressin and Desmopressin.
Key Facts
- PMID
- 27787700
- Journal
- Pediatric nephrology (Berlin, Germany)
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Kamperis K et al. (6 authors)
- DOI
- 10.1007/s00467-016-3536-9
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.
The researchers investigated the effect of combining indomethacin and desmopressin in treating children with monosymptomatic nocturnal enuresis (MNE) and desmopressin-resistant nocturnal polyuria.
Who Took Part
By PubMed's age tags, the people studied were children and teenagers, both men and women.
Twenty-three children with MNE, nocturnal polyuria, and partial or no response to desmopressin were recruited from incontinence clinics of their tertiary referral center.
Home recordings at baseline and for the final 2 weeks of each treatment period were performed and included nocturnal urine output measurements.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
Blinding on both sides kept the participants and researchers unaware of who received Vasopressin.
A placebo (an inactive look-alike) gave the Vasopressin group a baseline to be compared against.
Each person switched between Vasopressin and the comparison at some point, usually with a gap in between.
Student's t test and Pearson's correlation coefficient were used for statistical analysis.
What Was Measured
PubMed files the paper under topics including Anti-Inflammatory Agents, Non-Steroidal, Deamino Arginine Vasopressin, Indomethacin, Nocturnal Enuresis, Polyuria, Renal Agents and Urodynamics.
Author keywords: Children, Natriuresis, Nocturnal polyuria, Osmotic diuresis and Prostaglandins.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2017 (Pediatric nephrology (Berlin, Germany)), a journal based in Germany.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.