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The protective effect of human atrial natriuretic peptide on renal damage during cardiac surgery
Plain-language guide to PMID 27853882 (2017): randomized controlled trial study of ANP (Atrial Natriuretic Peptide).
Key Facts
- PMID
- 27853882
- Journal
- Journal of anesthesia
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Moriyama T et al. (6 authors)
- DOI
- 10.1007/s00540-016-2284-0
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ANP (Atrial Natriuretic Peptide).
Acute kidney injury (AKI) is one of the critical complications after cardiac surgery.
In the kidney, angiotensin II (Ang II) is formed by independent mechanisms, and activity of the intrarenal renin-angiotensin-aldosterone (RAAS) system contributes to the progression of kidney damage.
Although atrial natriuretic peptide (ANP) exerts protective effects against renal injury by inhibiting the RAAS, the mechanisms of this effect have not been completely clarified.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
Forty-eight patients undergoing cardiac surgery were divided into two groups, with and without hANP infusion.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got ANP (Atrial Natriuretic Peptide) and who got the comparison, which limits bias.
Urinary angiotensinogen, neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP) were measured during and after surgery in both groups.
Plasma renin activity, Ang II, aldosterone and serum creatinine were also measured.
What Was Measured
Topics PubMed links to this paper include Acute Kidney Injury, Angiotensin II, Atrial Natriuretic Factor, Cardiac Surgical Procedures, Cardiopulmonary Bypass, Fatty Acid-Binding Proteins and Kidney.
Author keywords: Cardiac surgery, Human atrial natriuretic peptide and Renin–angiotensin system.
What This Means in Plain Language
The paper is a randomized study of ANP (Atrial Natriuretic Peptide).
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2017 (Journal of anesthesia), a journal based in Japan.
More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.
Our Notes on the Compound
ANP (Atrial Natriuretic Peptide): A 28-amino-acid heart hormone that relaxes blood vessels and increases salt excretion; carperitide is a recombinant form.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.