Effects of Vitamin D on Endometriosis-Related Pain: A Double-Blind Clinical Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of endometriosis, published as a randomized controlled trial.

BACKGROUND Endometriosis is a disabling disease of reproductive-age women.

Dysmenorrhea, dyspareunia, and pelvic pain are the main symptoms of endometriosis.

Who Took Part

The study group was 19 patients.

By PubMed's age tags, the people studied were young adults and adults, women only.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

What Was Measured

MATERIAL AND METHODS In this double-blind clinical trial, the researchers enrolled patients with endometriosis diagnosed and treated by laparoscopy, with scores of at least 3 for of dysmenorrhea and/or pelvic pain at 8 weeks after surgical treatment.

Severity of pain in the 2 groups (placebo and treatment) was compared by VAS test at 24 weeks after surgical treatment.

PubMed files the paper under topics including Dysmenorrhea, Dyspareunia, Endometrial Ablation Techniques, Endometriosis, Laparoscopy, Pain Measurement and Pelvic Pain.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 19 patients in people with endometriosis.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2016 (Medical science monitor : international medical journal of experimental and clinical research), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Endometriosis research.