Omega-3 Fatty Acids and Vitamin D in Immobilisation: Part B- Modulation of Muscle Functional, Vascular and Activation Profiles.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

This study set out to determine whether two potential protein-sparing modulators (eicosapentaenoic acid and vitamin D) would modulate the anticipated muscle functional and related blood vessels function deleterious effects of immobilisation.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults and adults, both men and women.

Twenty-four male and female healthy participants, aged 23.0±5.8 years.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The study used a randomised, double-blind, placebo-controlled design.

The study took part in a laboratory setting.

The non-dominant arm was immobilised in a sling for a period of nine waking hours a day over two continuous weeks.

Isometric and isokinetic torque, antagonist muscle co-contraction (activation profile), muscle fatigability indices, and arterial resting blood flow were measured before, at the end of the immobilisation period, and two weeks after re-mobilisation.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Dietary Supplements, Docosahexaenoic Acids, Eicosapentaenoic Acid, Immobilization, Muscle, Skeletal and Vitamin D.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (The journal of nutrition, health & aging), a journal based in France.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.