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Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial.
Plain-language guide to PMID 28050798 (2017): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 58 women.
Key Facts
- PMID
- 28050798
- Journal
- Hormones & cancer
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Vahedpoor Z et al. (7 authors)
- DOI
- 10.1007/s12672-016-0278-x
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
This study was performed to evaluate the effects of long-term vitamin D administration on regression and metabolic status of patients with CIN1.
Why It Was Studied
The researchers are not aware of any study examining the effects of long term vitamin D administration on regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1).
This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with CIN1.
Who Took Part
According to the abstract, 58 women were involved.
PubMed indexes the participants as adults and middle-aged adults, women only.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the women and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
Fasting blood samples were taken at the beginning of the study and end-of-trial to measure related markers.
Topics PubMed links to this paper include Biomarkers, Biopsy, Calcifediol, Cholecalciferol, Colposcopy, Dietary Supplements and Glucose.
The authors tagged it with the keywords CIN1, Metabolic profiles, Regression, Supplementation and Vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 58 women.
The publication is from 2017 (Hormones & cancer), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.