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Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma
Plain-language guide to PMID 28068938 (2017): randomized controlled trial study of Cyanocobalamin (Vitamin B12) in 104 individuals.
Key Facts
- PMID
- 28068938
- Journal
- BMC cancer
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Han X et al. (12 authors)
- DOI
- 10.1186/s12885-016-3037-z
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy.
China Clinical Trials Register (registration no.
Who Took Part
According to the abstract, 104 individuals were involved.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
Of the patients, 98 out of 104 completed the treatment and follow-ups.
There were 49 patients in each group.
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.
The evaluating parameters included the visual analogue scale (VAS) pain score, Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire scores, and electromyographic (EMG) nerve conduction velocity (NCV) determinations.
The researchers evaluated the changes of the parameters in each group before and after the therapies and made a comparison between the two groups.
What Was Measured
The subject headings attached to it are Acupuncture Therapy, Antineoplastic Combined Chemotherapy Protocols, China, Combined Modality Therapy, Multiple Myeloma, Neoplasm Staging and Peripheral Nervous System Diseases.
The authors tagged it with the keywords CIPN and Methylcobalamin.
What This Means in Plain Language
The paper is a randomized study of Cyanocobalamin (Vitamin B12) in 104 individuals.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2017 (BMC cancer), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.