DOES VITAMIN D METABOLITE MEASUREMENT HELP PREDICT 25(OH)D CHANGE FOLLOWING VITAMIN D SUPPLEMENTATION?

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Variability in 25-hydroxyvitamin D (25(OH)D) change following vitamin D supplementation exists.

Vitamin D metabolite measurement might assist in predicting 25(OH)D response and also contribute to defining vitamin D adequacy.

This study assessed utility of vitamin D metabolite measurements to predict 25(OH)D response and explored the relationship between parathyroid hormone (PTH) and a "vitamin D composite index" comprised of the sum of serum 25(OH) D, cholecalciferol (vitamin D3) and 24,25 dihydroxyvitamin D (24,25(OH)2D).

Why It Was Studied

BMI = body mass index DXA = dual-energy X-ray absorptiometry LC-MS/MS = liquid chromatography tandem mass spectroscopy 25(OH)D = 25-hydroxyvitamin D 24,25(OH)2D = 24,25 dihydroxyvitamin D PTH = parathyroid hormone vitamin D3 = cholecalciferol.

Who Took Part

PubMed indexes the participants as middle-aged adults, older adults and people over 80, women only.

How the Study Was Run

The design is described as randomized and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Blood was drawn at baseline and after 1 and 4 months.

Serum 25(OH)D, vitamin D3, and 24,25(OH)2D were measured by liquid chromatography tandem mass spectroscopy.

Free 25(OH)D and PTH were measured by enzyme-linked immunosorbent assay.

Repeated measures analysis of variance and regression analyses were performed.

What Was Measured

Topics PubMed links to this paper include Body Mass Index, Cholecalciferol, Chromatography, Liquid, Dietary Supplements, Ergocalciferols, Parathyroid Hormone and Prognosis.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.