Comparing effects of insulin analogues and human insulin on nocturnal glycaemia in hypoglycaemia-prone people with Type 1 diabetes

What Was Tested

The paper reports a study of Insulin Aspart and NPH Insulin (isophane), published as a randomized controlled trial.

To assess the difference between analogue and human insulin with regard to nocturnal glucose profiles and risk of hypoglycaemia in people with recurrent severe hypoglycaemia.

Who Took Part

According to the abstract, 72 people were involved.

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Insulin Aspart and who got the comparison, which limits bias.

In the crossover set-up each of the people took both Insulin Aspart and the comparison in turn, acting as their own control.

Venous blood was drawn hourly during sleep.

What Was Measured

The subject headings attached to it are Blood Glucose, Circadian Rhythm, Diabetes Mellitus, Type 1, Hypoglycemia, Insulin, Insulin Aspart and Insulin, Isophane.

What This Means in Plain Language

The paper is a randomized and crossover study of Insulin Aspart and NPH Insulin (isophane) in 72 people.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (Diabetic medicine : a journal of the British Diabetic Association), a journal based in England.

More context: the Insulin Aspart compound page and the NPH Insulin (isophane) compound page, all human trials.