← Human Trials & Peer-Reviewed Studies
Vitamin A and Zinc Supplementation Among Pregnant Women to Prevent Placental Malaria: A Randomized, Double-Blind, Placebo-Controlled Trial in Tanzania.
Plain-language guide to PMID 28115667 (2017): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 625 participants.
Key Facts
- PMID
- 28115667
- Journal
- The American journal of tropical medicine and hygiene
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Darling AM et al. (13 authors)
- DOI
- 10.4269/ajtmh.16-0599
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The researchers undertook a randomized, double-blind placebo-controlled trial with a factorial design among 2,500 human immunodeficiency virus-negative primigravid or secundigravid pregnant women in their first trimester of pregnancy in Dar es Salaam, Tanzania.
Birth outcomes were obtained for 2,434 of the 2,500 randomized participants.
Who Took Part
The abstract describes 625 participants taking part.
PubMed tags the participants as women only.
A total of 625 participants were allocated to each treatment group.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
Birth outcomes were obtained for 2,434 of the 2,500 randomized participants.
Topics PubMed links to this paper include Dietary Supplements, Malaria, Falciparum, Placenta, Polymerase Chain Reaction, Pregnancy Complications, Parasitic, Pregnancy Outcome and Sensitivity and Specificity.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 625 participants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2017 (The American journal of tropical medicine and hygiene), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.