Teriparatide versus low-dose bisphosphonates before and after surgery for adult spinal deformity in female Japanese patients with osteoporosis

What Was Tested

This clinical trial paper looks at Teriparatide.

Complications of adult spinal deformity surgery are problematic in osteoporotic individuals.

Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age.

Who Took Part

The study group was 33 patients.

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, women only.

Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion.

How the Study Was Run

Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.

What Was Measured

PubMed files the paper under topics including Bone Density Conservation Agents, Diphosphonates, Osteoporosis, Postmenopausal, Perioperative Care, Spinal Curvatures and Teriparatide.

Author keywords: Disability evaluation, Orthopedic procedures/AE, Osteoporosis/SU and Teriparatide/TU bisphosphonates.

What This Means in Plain Language

This is a clinical trial of Teriparatide in 33 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Results are reported in around 2 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2017 (European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society), a journal based in Germany.

More context: the Teriparatide compound page, all human trials.