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Maternal and Fetal Folate, Vitamin B12, and Homocysteine Concentrations and Childhood Kidney Outcomes.
Plain-language guide to PMID 28143670 (2017): observational study of Cyanocobalamin (Vitamin B12) in 4,226 women.
Key Facts
- PMID
- 28143670
- Journal
- American journal of kidney diseases : the official journal of the National Kidney Foundation
- Year
- 2017
- Study type
- Observational Study
- Authors
- Miliku K et al. (6 authors)
- DOI
- 10.1053/j.ajkd.2016.11.014
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as an observational study.
Folate, vitamin B12, and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring.
The researchers examined the associations of folate, vitamin B12, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children.
Who Took Part
The study group was 4,226 women.
The age groups tagged for this paper are infants, young children and children, both men and women.
This study was performed among 4,226 pregnant women and their children.
How the Study Was Run
Population-based prospective cohort study from fetal life onward.
What Was Measured
The researchers examined the associations of folate, vitamin B12, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children.
Folate, vitamin B12, and homocysteine blood concentrations measured in early pregnancy (median gestational age, 13.2 [IQR, 12.2-14.8] weeks) and at birth (cord blood).
PubMed files the paper under topics including Albuminuria, Cohort Studies, Fetal Blood, Folic Acid, Glomerular Filtration Rate, Homocysteine and Kidney Function Tests.
Author keywords: Folate, epidemiology, estimated glomerular filtration rate (eGFR), fetal nutritional exposure, gestation and kidney development.
What This Means in Plain Language
This is an observational study of Cyanocobalamin (Vitamin B12) in 4,226 women.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2017 (American journal of kidney diseases : the official journal of the National Kidney Foundation), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.