Randomized Crossover Trial of Amoxapine Versus Vitamin B12 for Retrograde Ejaculation

What Was Tested

This randomized controlled trial paper looks at Cyanocobalamin (Vitamin B12).

Who Took Part

The study group was 26 men.

By PubMed's age tags, the people studied were adults and middle-aged adults, men only.

Between May 2009 and November 2012, this open-label, randomized, crossover study enrolled 26 men suffering with RE at Department of Reproductive Medicine, Omori Hospital.

Patients were randomly allocated into two groups (n=13 each).

How the Study Was Run

In design terms this was a randomized, open-label and crossover study.

Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.

Everyone knew when Cyanocobalamin (Vitamin B12) was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Each person switched between Cyanocobalamin (Vitamin B12) and the comparison at some point, usually with a gap in between.

The B12-amoxapine group received the opposite regimen.

All pa-tients masturbated to ejaculation at least twice during each treatment period.

The primary outcome was antegrade ejaculation of semen, as reported by the patient, on more than one occasion during either treatment period (defined as treatment success).

Any adverse events were noted.

Success rates were compared between treatments using Fisher's exact test.

What Was Measured

PubMed files the paper under topics including Amoxapine, Ejaculation, Selective Serotonin Reuptake Inhibitors, Sexual Dysfunction, Physiological, Vitamin B 12, Vitamin B 12 Deficiency and Vitamin B Complex.

The authors tagged it with the keywords Drug Therapy and Infertility, Male.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Cyanocobalamin (Vitamin B12) in 26 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2017 (International braz j urol : official journal of the Brazilian Society of Urology), a journal based in Brazil.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.