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Vitamin D supplementation in pregnancy, prenatal 25(OH)D levels, race, and subsequent asthma or recurrent wheeze in offspring: Secondary analyses from the Vitamin D Antenatal Asthma Reduction Trial.
Plain-language guide to PMID 28285844 (2017): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 28285844
- Journal
- The Journal of allergy and clinical immunology
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Wolsk HM et al. (13 authors)
- DOI
- 10.1016/j.jaci.2017.01.013
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The researchers sought to study the effect of a vitamin D intervention in pregnancy between subjects of different races and the association between 25-hydroxyvitamin D3 (25[OH]D) levels in pregnancy and the risk of asthma/recurrent wheeze in offspring.
Why It Was Studied
Nutrient trials differ from drug trials because participants have varying circulating levels at entry into the trial.
Who Took Part
The age groups tagged for this paper are young children, teenagers, young adults and adults, both men and women.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Asthma and recurrent wheezing until age 3 years were recorded.
What Was Measured
Nutrient trials differ from drug trials because participants have varying circulating levels at entry into the trial.
Topics PubMed links to this paper include Black or African American, Asthma, Calcifediol, Dietary Supplements, Prenatal Exposure Delayed Effects, Recurrence and Respiratory Sounds.
The authors tagged it with the keywords Vitamin D, allergy and randomized controlled trial.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2017 (The Journal of allergy and clinical immunology), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.