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Comparative Effects of an Angiotensin II Receptor Blocker (ARB)/Diuretic vs. ARB/Calcium-Channel Blocker Combination on Uncontrolled Nocturnal Hypertension Evaluated by Information and Communication Technology-Based Nocturnal Home Blood Pressure Monitoring - The NOCTURNE Study.
Plain-language guide to PMID 28321001 (2017): multicenter randomized controlled trial of Angiotensin II in 411 patients, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 28321001
- Journal
- Circulation journal : official journal of the Japanese Circulation Society
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Kario K et al. (12 authors)
- DOI
- 10.1253/circj.CJ-17-0109
What This Study Did, in Plain Language
What Was Tested
Researchers studied Angiotensin II in the context of low blood pressure and orthostatic hypotension in this randomized controlled trial publication.
The NOCTURNE study, a multicenter, randomized controlled trial (RCT) using their recently developed information and communication technology (ICT) nocturnal home BP monitoring (HBPM) device, was performed to compare the nocturnal HBP-lowering effects of differential ARB-based combination therapies in 411 Japanese patients with nocturnal hypertension (HT).
Why It Was Studied
Nocturnal blood pressure (BP) is an independent risk factor of cardiovascular events.
Who Took Part
According to the abstract, 411 patients were involved.
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized and multicenter.
The patients were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.
More than one site took part, so the patients came from several places.
What Was Measured
The subject headings attached to it are Amlodipine, Angiotensin Receptor Antagonists, Biphenyl Compounds, Blood Pressure Monitoring, Ambulatory, Calcium Channel Blockers, Communication and Diuretics.
Author keywords: Angiotensin II receptor blockers (ARBs), Calcium-channel blockers (CCBs), Information and communication technology (ICT)-based home blood pressure monitoring and Nocturnal blood pressure.
What This Means in Plain Language
The paper is a randomized and multicenter study of Angiotensin II in 411 patients in people with low blood pressure and orthostatic hypotension.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2017 (Circulation journal : official journal of the Japanese Circulation Society), a journal based in Japan.
More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.