Pigment Epithelium-Derived Factor Declines in Response to an Oral Glucose Load and Is Correlated with Vitamin D and BMI but Not Diabetes Status in Children and Young Adults.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this clinical trial publication.

The researchers investigated the relationship between PEDF and various metabolic biomarkers in young healthy volunteers (HV) and similar-aged patients with diabetes (type 1 and type 2).

Who Took Part

The study group was 11 patients.

By PubMed's age tags, the people studied were teenagers, young adults and adults, both men and women.

A fasting blood sample was collected in 48 HV, 11 patients with type 1 diabetes (T1D), and 11 patients with type 2 diabetes (T2D) 12-25 years of age.

In 9 healthy subjects, PEDF was also serially measured during a frequently sampled oral glucose tolerance test (OGTT).

What Was Measured

The subject headings attached to it are Blood Glucose, Body Mass Index, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Eye Proteins, Glucose Tolerance Test and Nerve Growth Factors.

The authors tagged it with the keywords Adolescents, Bone, Metabolism and Obesity.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 11 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2017 (Hormone research in paediatrics), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.