Maternal left ventricular hypertrophy and diastolic dysfunction and brain natriuretic peptide concentration in early- and late-onset pre-eclampsia

What Was Tested

Researchers studied BNP (Nesiritide) in this observational study publication.

The aim of this study was to assess and compare maternal left ventricular structure and diastolic function and levels of brain natriuretic peptide (BNP) in women with early-onset (< 34 weeks' gestation) vs those with late-onset (≥ 34 weeks' gestation) PE.

Who Took Part

The study group was 30 women.

The age groups tagged for this paper are young adults and adults, women only.

This was a prospective, cross-sectional, observational study of 30 women with early-onset PE, 32 with late-onset PE and 23 normotensive controls.

How the Study Was Run

Maternal cardiac structure and diastolic function were assessed by echocardiography and plasma levels of BNP were measured by enzyme immunoassay.

What Was Measured

PubMed files the paper under topics including Biomarkers, Cross-Sectional Studies, Disease Progression, Echocardiography, Hypertrophy, Left Ventricular, Natriuretic Peptide, Brain and Pre-Eclampsia.

Author keywords: brain natriuretic peptide, cardiac hypertrophy, diastolic function, early-onset pre-eclampsia and late-onset pre-eclampsia.

What This Means in Plain Language

This is an observational study of BNP (Nesiritide) in 30 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2018 (Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology), a journal based in England.

More context: the BNP (Nesiritide) compound page, all human trials.