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Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial.
Plain-language guide to PMID 28448457 (2017): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 28448457
- Journal
- Nutrients
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Schwetz V et al. (16 authors)
- DOI
- 10.3390/nu9050432
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Bone turnover markers (BTMs) are used to evaluate bone health together with bone mineral density and fracture assessment.
Why It Was Studied
The researchers therefore examined the effects of vitamin D supplementation on bone-specific alkaline phosphatase (bALP), osteocalcin (OC), C-terminal telopeptide (CTX), and procollagen type 1 N-terminal propeptide (P1NP).
This is a post-hoc analysis of the Styrian Vitamin D Hypertension Trial, a single-center, double-blind, randomized, placebo-controlled trial (RCT) performed at the Medical University of Graz, Austria (2011-2014).
Who Took Part
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
Topics PubMed links to this paper include Alkaline Phosphatase, Biomarkers, Bone Remodeling, Gene Expression Regulation, Osteocalcin, Peptide Fragments and Procollagen.
Author keywords: bone turnover markers, bone-specific alkaline phosphatase, crosslaps, procollagen type 1 N-terminal propeptide and vitamin D supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2017 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.