Impact of Zinc Supplementation on the Clinical Outcomes of Patients with Severe Head Trauma: A Double-Blind Randomized Clinical Trial.

Plain-language guide to PMID 28467150 (2018): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 100 patients.

Key Facts

PMID: 28467150
Journal: Journal of dietary supplements
Year: 2018
Study type: Randomized Controlled Trial
Authors: Khazdouz M et al. (6 authors)
DOI: 10.1080/19390211.2017.1304486

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Glasgow outcome score (GOS), mortality rate on day 28, and length of stay (LOS) were compared between groups.

Who Took Part

According to the abstract, 100 patients were involved.

The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults and older adults, both men and women.

Plasma zinc and copper, 24-hour urinary zinc excretion, Sequential Organ Failure Assessment (SOFA) were assessed on days 1, 7, and 16.

Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and white blood cell (WBC) count were measured on days 1 and 16.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

What Was Measured

Glasgow outcome score (GOS), mortality rate on day 28, and length of stay (LOS) were compared between groups.

Topics PubMed links to this paper include Biomarkers, Blood Sedimentation, C-Reactive Protein, Craniocerebral Trauma, Dietary Supplements, Glasgow Outcome Scale and Length of Stay.

Author keywords: GCS, SOFA, severe head trauma and zinc administration.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 100 patients.

The publication is from 2018 (Journal of dietary supplements), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.