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Functional network connectivity predicts treatment outcome during treatment of nicotine use disorder.
Plain-language guide to PMID 28525877 (2017): randomized controlled trial of Therapeutic nicotine (patch, non-peptide).
Key Facts
- PMID
- 28525877
- Journal
- Psychiatry research. Neuroimaging
- Year
- 2017
- Study type
- Randomized Controlled Trial
- Authors
- Wilcox CE et al. (8 authors)
- DOI
- 10.1016/j.pscychresns.2017.04.011
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Therapeutic nicotine (patch, non-peptide).
The researchers hypothesized that higher connectivity between insula and 1) dorsal anterior cingulate cortex (dACC) and 2) dorsolateral prefrontal cortex (dlPFC) would predict better treatment outcomes.
The researchers also performed an exploratory analysis of the associations between FNC values between additional key frontal and striatal regions and treatment outcomes.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.
What Was Measured
The researchers hypothesized that higher connectivity between insula and 1) dorsal anterior cingulate cortex (dACC) and 2) dorsolateral prefrontal cortex (dlPFC) would predict better treatment outcomes.
The researchers also performed an exploratory analysis of the associations between FNC values between additional key frontal and striatal regions and treatment outcomes.
PubMed files the paper under topics including Brain, Corpus Striatum, Gyrus Cinguli, Magnetic Resonance Imaging, Nerve Net, Nicotinic Agonists and Smoking.
The authors tagged it with the keywords Functional network connectivity, Nicotine dependence, Prediction, Resting state, Treatment and Treatment outcome.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).
The publication is from 2017 (Psychiatry research. Neuroimaging), a journal based in Netherlands.
More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.
Our Notes on the Compound
Therapeutic nicotine (patch, non-peptide): Pure nicotine as a signaling tool, separated from smoking and vaping.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.